Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection
Figure 4
Efficacy in porcine wound healing of IDR-1018 compared to LL-37.
(A) Efficacy in an infected porcine model of wound healing by IDR-1018. Digital photographic overview of porcine wounds treated with IDR-1018 (20 or 200 µg/ml every 48 hours) compared to LL-37 (200 µg/ml, positive control) and PBS (carrier control). (B) Quantification of re-epithelialization in wounds treated with IDR-1018. Re- epithelialization was assessed with IDR-1018 (20 and 200 µg/ml), LL-37 (200 µg/ml) or PBS. For day 0 to day 6 each value was calculated as mean out of six wounds while values of day 8 and 10 were calculated out of three different wounds. The bars represent standard error of the mean wound closure (*,+ = p<0.05; **,++ = p<0.01 (*IDR-1018 200 µg/ml; +IDR-1018 20 µg/ml) compared to vehicle control).