Inhibition of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels and Increases Glycolysis Rates following Diet-Induced Insulin Resistance
Figure 9
Myriocin treatment of db/db mice decreases intra-myocardial ceramide levels but has no effect on intra-myocardial DAG content.
A: Intra-myocardial ceramide, and B: DAG levels in db/db mice treated with vehicle control or myriocin. Values represent mean ± SE (n = 4–6). Differences were determined using an unpaired Student’s two-tailed t-test. *P<0.05, significantly different from vehicle control counterpart.