Targeting of the Human Coagulation Factor IX Gene at rDNA Locus of Human Embryonic Stem Cells
Figure 5
Teratoma formation in immunodeficiency mice by targeted cells.
H&E staining of teratomas was performed. Derivatives of all three germ layers were observed in the endoderm: (a) gallbladder, (b) intestinal-like epithelium, and (c) respiratory epithelium; in the mesoderm, (d) cartilage and (e) muscle; and in the ectoderm, (f) squamous epithelium. Bar = 200 µm.