Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells
Figure 1
Viability of the MCF-7R and MCF-7S cells.
Cells were treated with (A) DOX (0–300 nM), (B) NCTD (0–50 µM), (C) a combination of DOX (150 nM) and/or NCTD (10 µM), and (D) a combination of VNR (0.5 nM), Shh peptide (0.1 µg/mL) and/or NCTD (10 µM). After 48 h, the cell viability was assayed by the MTT method. The results were expressed as the mean ± SD of at least three independent experiments. *Significant difference compared with the untreated control group.