Functional Changes in Muscle Afferent Neurones in an Osteoarthritis Model: Implications for Impaired Proprioceptive Performance
Figure 5
Excitability of muscle afferent neurones determined by depolarizing current injection in control and OA animals.
2nA direct current was injected into neurones at 4 weeks after surgery in control and in OA animals. (A and B) show repetitive firing in a control and an OA muscle afferent neurone, respectively. In both recordings, the upper trace indicates the 2 nA depolarizing current, and the lower trace is the intracellular recording signal. (C) Shows the histogram showing the number of neurones with various evoked APs following depolarizing current injection in both control and OA muscle afferent neurones. (D) Shows the comparison of the number of APs evoked by 2 nA direct current injection between OA (N = 37) and control (N = 25) muscle afferent neurones. The Mann-Whitney U-test was used.