Pattern Classification of Large-Scale Functional Brain Networks: Identification of Informative Neuroimaging Markers for Epilepsy
Figure 4
Asymmetry measure ρ for 45 pairs of equivalent brain regions a, Visualization of ρ for all subjects, with each row corresponding to a subject, and each column represents each pair of equivalent brain regions.
The top 80 rows are healthy controls, and the bottom 100 rows are epileptic patients, separated by a black dashed line. A large ρ indicates a high level of asymmetry. b, The ratio between group mean value (ρ_P/ρ_H) for each pair of brain regions. The red dashed line corresponds to ρ_P/ρ_H = 1, i.e., the two groups have the same group mean value. The most asymmetric brain region according to ρ_P/ρ_H (i.e., amygdale), is highlighted. c, The 10 most discriminative regions across the two groups according to P value of two sample t-test, with the mean and standard deviation of ρ being shown for the two groups. The corresponding P values are (unit: 10−3): 0.0002, 0.0017, 0.0027, 0.0031, 0.0234, 0.2620, 0.6166 0.6511, 0.7256, 1.1926. Other significantly changed regions (P<0.01/45) include Occipital_Inf, Temporal_Sup, Parietal_Inf, Temporal_Mid, Calcarine, and Frontal_Mid. As is shown, ρ is much larger for epileptic patients than for healthy controls.