Stemness of the Organ of Corti Relates to the Epigenetic Status of Sox2 Enhancers
Figure 7
Methylation patterns of the otic Sox2 enhancers NOP1 and NOP2 are differentially regulated with regard to stemness and otic differentiation.
(A,B) The complete NOP1/2 datasets were analyzed by a circular map to visualize the relationships between analyzed elements with respect to the topology inherent in the data. NOP1 and NOP2 methylation levels of OC (E13.5, P4 and P21) as compared to OCSC, OCSC+EGF and differentiating epithelial island (28 DIV). The map is similar to clustering, but the arrangement is circular rather than linear to emphasize the periodicity of the angular positions and to allow comparisons across conditions and factors.