JC Virus Encephalopathy Is Associated with a Novel Agnoprotein-Deletion JCV Variant
Figure 1
Genomic map and organization of regulatory region of JCVCPN1.
A. The genomic map of JCVCPN1 shows a 143 bp deletion in the Agno gene (nt 300–442), yielding a truncated 10 aa Agno peptide, the last two aa being mutated. B. Alignment of the regulatory region (RR) of JCVCPN1 with the RR of prototype JCV Mad-1, usually found in CNS of PML patients and archetype JCV RR, most commonly found in urine of healthy and immunosuppressed patients alike. JCVCPN1 has an archetype-like RR structure with a 19 bp deletion in the 98 bp element, a 3 nt deletion in the 23 bp insert and a complex mutation in the 66 bp insert, yielding a 80 bp insert. The whole nt sequence of the archetype 66 bp insert (*) and corresponding changes in the 80 bp insert of JCVCPN1 RR (**) are indicated.