Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12
Figure 4
LLL12 inhibits angiogenesis in mice.
Matrigel plugs containing PBS (Control), or VEGF (100 ng/ml) were implanted subcutaneously in mice that were or were not treated with LLL12 (5 mg/kg daily). The Matrigel plugs were excised on day 7, fixed with formalin and 5-µm sections were stained for CD34 staining. The numbers of CD34 positive vessels per high power field (HPF, magnification, 200×) were counted for each experimental condition. Results are mean (n = 4) ± SE. *P<0.05; versus VEGF alone.