Thrombospondin-1 Type 1 Repeats in a Model of Inflammatory Bowel Disease: Transcript Profile and Therapeutic Effects
Figure 3
Differentially expressed genes in paired sets of comparison between the treatment and the control groups.
Comparison of treatment groups with WT-water (A, upper panel of table) and WT-DSS saline controls (A, lower panel). Total DE genes refer to all genes that are up- or down-regulated by >1.5-fold at 95% confidence level. The 3TSR-treatment group clearly shows the least transcriptional perturbation among the TSR treatment groups. (B) A heatmap of the top 12 DE genes in the comparison that uses WT-water as the control. Capsl, Cbr3, Abhd3 and 0610011F06Rik are down-regulated in the TSR treatment groups. (C) A heatmap of the top DE genes in the 3TSR-treated group. The number of up- and down-regulated genes in the TSR treatment groups (when compared to the WT-water control) are presented in (D); (E) shows the breakdown of the DE genes in comparison to the WT-DSS saline.