X4 Human Immunodeficiency Virus Type 1 gp120 Promotes Human Hepatic Stellate Cell Activation and Collagen I Expression through Interactions with CXCR4
Figure 5
Gp120 is present in liver tissue from HIV/HCV infected patients.
Paraffin-embedded liver biopsies from HIV/HCV coinfected patients prior to initiation of ART were immunostained with monoclonal anti-gp120 or isotype control. Sinusoidal staining was appreciated in all 3 specimens. Representative images shown (Magnification 100×, 630×). Viral load ranges: HIV RNA levels ranged from 514–2,455 copies/ml; HCV RNA levels ranged from 1.2 million–1.6 million IU/ml.