A Human PrM Antibody That Recognizes a Novel Cryptic Epitope on Dengue E Glycoprotein
Figure 7
Effect of DENV maturation state on ADE profile by D29 Fab-IgG.
(A) The specific infectivity of DENV2 and imDENV2 was determined. Serially diluted anti-DENV antibodies were incubated with (B) DENV2 or (C) imDENV2 at MOG 25 for 1 hr at 37oC before infection of 2×104 K562 cells for 2 days. Viral titer was quantified by plaque assay (limit of detection is 0.5×102 pfu/ml). Data presented is the average of three independent experiments with error bars representing the standard deviation.