Uropathogenic Escherichia coli Induces Serum Amyloid A in Mice following Urinary Tract and Systemic Inoculation
Figure 1
Induction and localization of SAA1/2 following inoculation of the bladder with UPEC.
Immunofluorescence miscroscopy of bladder sections showing SAA1/2 (red) levels and distribution in sham-infected (PBS-treated) mice (A) and mice that were infected for either one (B) or four days (C) via intravesical instillation of the UPEC isolate UTI89. (D and E) Localization of UPEC (green) with host cell nuclei (blue) and SAA1/2 at 4 d post - inoculation of the bladder with UTI89. Large arrows point to the apical membrane of urothelium and bars mark the border between urothelium and lamina propria. Small arrows indicate a few bacteria that do not co-localize with SAA1/2.