Interaction Pattern of Arg 62 in the A-Pocket of Differentially Disease-Associated HLA-B27 Subtypes Suggests Distinct TCR Binding Modes
Figure 1
MHC:peptide complex unbound (A) and bound (B) to a TCR.
A) Cartoon representation of HLA*B2705 presenting the pLMP2 peptide (PDB ID: 1UXS). The peptide-binding groove is shown in beige, the α3 domain in red, the β2-microglobulin in green and the bound LMP2 peptide in blue. Arg62 and Glu163 are emphasized in stick representation. B) Cartoon representation of the binding groove of HLA-B*0801 (in beige) in complex with an EBV derived nonapeptide (in purple) bound to the Vα and Vβ chains of the LC13 T-Cell receptor (in green, PDB ID: 1MI5). Arg62 of the MHC binding groove as well as the residues of the Vα chain making contacts with Arg62 (Thr26, Ser28 and Gly96) are shown in stick representation.