Kainate Receptor-Mediated Modulation of Hippocampal Fast Spiking Interneurons in a Rat Model of Schizophrenia
Figure 1
AP firing rate is decreased while AHP is increased in SO of CA2/3 fast–spiking interneurons of PICRO-treated rats in the presence of kainic acid (KA).
Application of KA does not affect duration (A) or RMP (B) in PICRO-treated rats compared to experimental conditions with no drug. In contrast, AHP is increased (C) and AP firing rate is decreased in PICRO rats compared with saline–infused animals in the presence of KA (D, E). Insets in C, E show representative traces of interneuron AP responses from SAL (on the left) and PICRO (on the right) infused animals. F, Plot of instantaneous firing frequency versus time for spikes elicited by single current steps during the first 500 ms of a 1s current pulse in slices from PICRO rats with or without KA in the external solution. * p = <0.05 or ***p<0.001. Error bars indicate SEM.