The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways
Figure 4
Effect of ErbB2 and MUC4 on tumour growth in vivo.
(A) Subcutaneous xenograft of MUC4-KD (M4-2-1 and M4-2-10), ErbB2-KD (EV9 and EV18) and control (Mock-1 and NT5) cells were performed in six SCID mice. Relative tumour size was determined at day 22. (B) IHC analysis of MUC4 and ErbB2 expression was analysed on extracted tumours. MUC4 is expressed at the membrane surface and within the cytoplasm in Mock cells (insert). ErbB2 is expressed at the membrane surface in NT control cells (insert).