Optimizing Preprocessing and Analysis Pipelines for Single-Subject fMRI: 2. Interactions with ICA, PCA, Task Contrast and Inter-Subject Heterogeneity
Figure 7
Effects of pipeline optimization on group-level activation, strong contrast.
Activation structure is shown for strong (Task vs. Control) contrast, under fixed (FIX) and individually-optimized (IND) preprocessing. (A) mean Z-scored activation maps for FIX and IND (top), and mean Z-score change (bottom), with significance given by bootstrap estimation (1000 iterations), thresholded at False-Discovery Rate (FDR) 0.05. (B) between-subject SPM correlations, for both FIX and IND pipeline sets. (C) between-subject Jaccard activation overlap, for voxels significant at FDR = 0.05. For (B–C), each point represents mean correlation/overlap of one subject with all others; blue lines show an increase in correlation/overlap with IND, and red lines show a decrease.