Pregnane X Receptor and Yin Yang 1 Contribute to the Differential Tissue Expression and Induction of CYP3A5 and CYP3A4
Figure 1
The activities of proximal CYP3A4 (374 bp) and CYP3A5 (370 bp) promoters in kidney-derived MDCK.2 cells (A) and in small intestine-derived LS174T cells (B).
Data are expressed as mean values (±SEM) of six independent experiments conducted as triplicates. Promoter-driven firefly luciferase activities in the individual wells were normalized using activities of the co-transfected renilla luciferase driven by a constitutive promoter. Statistically significant differences are indicated by asterisks (*** p<0.001).