In Vitro and In Vivo Investigation of the Efficacy of Arylimidamide DB1831 and Its Mesylated Salt Form - DB1965 - against Trypanosoma cruzi Infection
Figure 2
Treatment of T. cruzi-infected mice (104 Y strain/mice) with DB1965.
The activity of 5 (E–F), 12.5 and 25 (A–D) mg/Kg/day of DB1965 (ip) and 100 mg/kg/day DB1965 via p.o (A–B) is presented. As reference drug, 50 and 100 mg/Kg/day benznidazole (by p.o) was also evaluated using similar therapeutic schemes at the 5–9 dpi (A–B), 5–14 dpi (C–D) and 5–24 dpi (E–F). Parasitaemia curves (A, C and E) and percentage of cumulative mortality (B, D and F) are shown. All assays were run at least two times.