Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury
Figure 4
bpV-treatment enhances forelimb functional recovery.
A) By 6 weeks post-injury, bpV(pic)-treated rats exhibited significantly enhanced forelimb function over vehicle-treated animals as scored using an 8-point treat manipulation behavioral scale (6.8 vs. 4.5). Sham animals scored at or near perfect (8 points) throughout the study. B) Testing scores showed a positive linear correlation with arm joint articulation ability (R2 = 0.88). C) Images portraying a rat grasping and manipulating a flavored cereal ring, the treat used in this assessment. **, p<0.01; *, p<0.05. n = 4−5. Error bars = SEM.