Catechol-O-Methyltransferase Val158Met Polymorphism Associates with Individual Differences in Sleep Physiologic Responses to Chronic Sleep Loss
Figure 1
Hourly slow-wave energy (SWE) and slow-wave activity (SWA) during baseline for the COMT Val158Met genotypes.
Mean (±SEM) hourly SWE and SWA derived from the C3 (A, B), Fz (C, D) or O2 (E, F) channels during baseline for Met/Met (open circles), Val/Met (gray triangles) and Val/Val (closed circles) subjects. As expected, SWE and SWA showed a typical pattern of dissipation across the baseline night in all 3 channels in all genotypes (denoted by *, p<0.0001), but did not show a differential pattern of decline across genotypes. The groups also did not show significant differences in SWE or SWA derived from the C3, Fz or O2 channels. In some records, EEG signal quality was insufficient or contained too much artifact for reliable power spectral analysis. Thus, the final sample sizes were as follows: for C3, Met/Met (n = 19), Val/Met (n = 60), and Val/Val (n = 39) subjects; for Fz, Met/Met (n = 18), Val/Met (n = 62), and Val/Val (n = 42) subjects; for O2, Met/Met (n = 19), Val/Met (n = 61), and Val/Val (n = 44) subjects.