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Systematic Evaluation of the Metabolic to Mitogenic Potency Ratio for B10-Substituted Insulin Analogues

Figure 2

Representative dose-response profiles for mitogenic potency determination.

Human insulin (•) or insulin analogue (B10D (♦), B10E (▪), or B10A (▾)) stimulated incorporation of [³H]-thymidine into DNA is shown in (A) L6-hIR cells and (B) HMECs. Data points are means ± SEM (n = 3).

doi: https://doi.org/10.1371/journal.pone.0029198.g002