Latent Epstein-Barr Virus Can Inhibit Apoptosis in B Cells by Blocking the Induction of NOXA Expression
Figure 1
Latent EBV inhibits ionomycin-induced apoptosis in a variety of cell backgrounds.
(A) BL41 and its EBV-positive counterparts, BL41/B95.8 and BL41/P3HR1, and two Wp-restricted BL Oku-BL and Sal-BL, (B) BL2 and its EBV-positive convert established with a recombinant EBNA2-knockout virus (BL2+E2KO), (C) Mutu III (expressing all the latency-associated proteins) and Mutu I (expressing only EBNA1) and (D) two LCLs were all treated with 1 µg/ml ionomycin (IM) for up to 48 hours. Viable cells (assessed by trypan blue exclusion) were counted. Cell survival is expressed as a percentage relative to the starting population and the mean and standard deviation of viable cell counts from three independent experiments are shown.