NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats
Figure 7
NDRG2 promotes hepatocyte proliferation without inducing apoptosis.
(A) Immunohistochemistry and TUNEL staining were used to determine the expression of PCNA (200×) and cell apoptosis (400×) in normal and DMN-induced fibrotic rat livers following PBS or adenovirus treatment. Semiquantitative analysis of PCNA staining (B) and TUNEL staining (C). “normal” means rats without treatment. *P<0.05 compared with the PBS or AdLacZ group.