Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses
Figure 1
Substrate specificity of 3CLpro at P5 to P3' positions.
Relative protease activity of 3CLpro from HCoV-NL63 (circles, group 1), HCoV-OC43 (squares, group 2a), SARS-CoV (diamond, group 2b) and IBV (triples, group 3) against 19×8 of substrate variants were measured by FRET assay. Relative activities that are significantly (p-value<0.001) higher than the rest are represented as filled symbols.