Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α
Figure 7
PGC-1β regulates mitochondrial gene expression in 3T3-L1 adipocytes.
(A) PGC-1α and PGC-1β expression in 3T3-L1 adipocytes transfected with siRNAs specifically targeting PGC-1α or PGC-1α. (B) Expression of mitochondrial genes CYCS, IDH3β, ATP5B and NDUFB9 in adipocytes transfected with siRNA for PGC-1α or PGC-1β knockdown or siRNA control, and treated with vehicle (DMSO) or rosiglitazone (Rosig). Results are expressed as mean ± SEM of 3 independent experiments with triplicates. *P<0.05, **P<0.01.