Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns
Figure 7
Results of Latent Cluster Analysis (LCA) applied to the population of preterm newborns in the study.
(A) Profile plot of the 2-cluster model solution segregating the preterm newborn in this study (n = 180) by probability of antenatal exposure to intra-amniotic infection and/or inflammation (IAI). The x-axis lists the discriminative indicators and significant covariates with their modal characteristic (in red) for which the probability level expected to manifest in each of the two latent clusters is displayed on the y-axis. Newborns in cluster-1 are characterized by low probability of a switch-on haptoglobin (Hp) pattern, IL-6≥100 pg/mL hematological indices consistent with presumed early-onset sepsis (EONS). In contrast, newborns in cluster-2 are characterized by high probability of Hp switch-on pattern along with increased probabilities for cord blood IL-6≥100 pg/mL and for presumed EONS.