Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation
Figure 1
The numbers at right are the %identity/%overall identity and similarity for each indicated domain of ICN2, ICN3, and ICN4 relative to ICN1, based on sequence alignments and homology calls performed by Clustal. Similarity is defined as positions with conservative or semi-conservative substitutions. N.S. indicates no significant homology. Domain boundaries were defined based on ICN1, in which the RAM domain and flanking C-terminal sequences span residues 1761 to 1872; the ankyrin repeat domain (ANK) spans residues 1873 to 2123; an ANK flanking region (AFR) spans residues 2124 to 2204; the transcriptional activation domain spans residues 2205 to 2422 [10]; and the C-terminal domain including the PEST degron spans residues 2423 to 2556.