Age-Related Differences in Naturally Acquired T Cell Memory to Plasmodium falciparum Merozoite Surface Protein 1
Figure 5
MSP1-specific IFN-γ responses generated from both CD+4 and CD8+ T cells.
IFN-γ responses to MSP142 (3D7 strain) were determined ex vivo by intracellular staining and flow cytometric analysis of cell surface marker expression. The frequency of IFN-γ positive responses per 100 CD4+ T cells (A) and CD8+ T cells (B) after ex vivo rMSP142 stimulation were compared between children (≤5 years) and adults (≥18 years). There were no significant differences in the median number of IFN-γ responses generated by either CD4+ or CD8+ T cells by age group.