Antitumor Effect of Malaria Parasite Infection in a Murine Lewis Lung Cancer Model through Induction of Innate and Adaptive Immunity
Figure 1
Malaria parasite infection suppresses tumor growth and metastasis in a mouse model.
A, Tumor growth was measured over time (n = 12). The graph shows average with SD. B, Tumor mass 17 days after tumor cell inoculation (n = 10). C, Metastasis development 35 days after tumor inoculation. The graph shows the number of lung and liver tumors in the LLC and LLC+Py mice (n = 10). D, Number of lung tumor nodules in mice 18 days after intravenous tumor inoculation (n = 21). E, Examples of metastatic nodules in the lungs of mice in D. F, Survival curve of LLC and LLC+Py group mice (n = 11). All experiments were performed three times with similar results. Statistical differences between groups are indicated by the P values.