Myostatin Is Elevated in Congenital Heart Disease and After Mechanical Unloading
Figure 4
A.) Representative Western blot for MEF-2, a transcriptional factor for myostatin, in Adult Normal (n = 5), pediatric right ventricular outflow tract (RVOT) (n = 3), pediatric orthotopic heart transplant (OHT) (n = 7 paired LV and RV), and pediatric biventricular assist device (BiVAD) myocardial tissue samples (n = 3 paired LV and RV). B.) MEF-2 was significantly increased in LV-OHT compared to Adult Normal control (#p<0.05). In addition, BiVAD support increased MEF-2 significantly over all patient groups in both RV and LV samples (*p<0.05 vs. Adult Normal, RVOT, RV-OHT, LV-OHT).