Specificity and Actions of an Arylaspartate Inhibitor of Glutamate Transport at the Schaffer Collateral-CA1 Pyramidal Cell Synapse
Figure 3
Representative recordings from outside-out patches excised from CA1 pyramidal neurons illustrating AMPAR and NMDAR responses to rapid application of 100 µM L-glutamate and/or 100 µM L-TBA for durations indicated by solution exchange traces above.
Responses at −60 mV showing lack of agonist or antagonist actions of L-TBA on AMPARs (A; with 1.2 mM Mg2+) and NMDARs (B; with 0 mM Mg2+/20 µM glycine/20 µM CNQX). Scale bars are 50/200 ms and 50/100 pA for AMPAR/NMDAR responses respectively. (C) Summary of mean effects of 100 µM L-TBA on 100 µM L-Glu AMPAR and NMDAR responses.