Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis
Figure 1
Efficient uptake of WT or mutant Lnk R8 fusion proteins.
(A) Diagram of WT or mutant Lnk R8 constructs. Pro-rich:Proline-rich domain, PH:Pleckstrin homology domain, SH2:Src Homology 2 domain. (B) Coomassie blue staining of purified WT Lnk R8 or mutant Lnk R8. (C) Western blotting using anti-Lnk antibody confirmed the 70 kDa bands as WT and mutant Lnk R8. (D) Flow cytometry data showing internalization efficiency of FITC-labeled WT or mutant Lnk R8 in M-MOK cells.