Force-Induced Unfolding Simulations of the Human Notch1 Negative Regulatory Region: Possible Roles of the Heterodimerization Domain in Mechanosensing
Figure 4
Representative snapshots of the human Notch1 NRR along the force-induced unfolding pathway during one of the SMD pulling simulations.
The LNR-A, LNR-B and LNR-C modules are colored in blue, green and red, respectively, and the HDN and HDC subunits of the HD domain in cyan and purple, respectively. The N- and C-terminal Cα beads where the external force is exerted are shown in black spheres. The S2 site is marked using purple spheres. Approximate end-to-end distances for the snapshots are also listed. Note that the magnified view of the 166 Å snapshot is slightly rotated to better show the exposure of the S2 site.