Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide
Figure 3
Immunohistochemistry of relevant proteins in SHR carotid artery.
A) Immunohistochemical staining (left, typical staining images; 200× magnification) and quantification (right) of SHR or WKY carotid artery segments depicting cell nuclei staining (blue), with/without the von Willebrand Factor (vWF) endothelium marker (green) and cyclooxygenase-1 (COX-1; red). B) thromboxane synthase (TXAS; red) and C) calcium-independent phospholipase A2 (iPLA2; red). Please note the increased EC/VSMC iPLA2 expression ratio in SHR. Data presented as mean ± SEM, n = 5–6, (*) p<0.05, scale bars 100 µm.