Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye
Figure 8
The hypothesized mecanisms regulating recuritment of retinal microgila to CNV.
The inflammatory cells in CNV could be recurited retinal microgila, which settle in the inner retina under normal conditions or macrophages from bone marrow that access CNV lesions via blood flow through the choroid. Laser injury up-regulated expression of PlGF, VEGF-A and –B, and VEGFR1 and 2 and could create gradients of some chemotractant factors such as CCL-2 and SDF-1, etc, with higher concentrations in the outer reitna and lower concentrations in the inner retina. The retinal microglial migration towards the CNV was driven by these chemotractant singaling molecues and their further infiltration and activation in CNV are dependent on PlGF-VEGF/VEGFR1 and 2 signaling systems. The exact mechanms controling the recruitment of macrophages is unclear. Line: activation; dished lines: blockade or inhibition.