Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice
Figure 7
Reduced forelimb grip strength in male Srd5α1−/− mice.
Grip strength in four-month-old gonadal intact (sham-operated) Srd5α1−/− (KO; n = 18) and wild type (WT; n = 27) mice. In addition, four-month-old orchidectomized (orx) KO and WT mice were either treated with placebo (Orx) or testosterone (Orx+T) for four weeks (WT orx n = 13, WT orx+T n = 13, KO orx n = 8, KO orx+T n = 8). Values are means ± SEM. * p<0.05 Student's t-test versus WT.