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Physical Exercise Regulates p53 Activity Targeting SCO2 and Increases Mitochondrial COX Biogenesis in Cardiac Muscle with Age

Figure 4

Mitochondrial transcription cascade in cardiac muscle.

A: Mitochondrial transcription cascade from mice at different age. Data are presented as mean ± SEM (n = 8) and displayed as fold changes vs. mice at 4 months of age. The statistical significance of differences was calculated by using one-way ANOVA. *P<0.05 vs. mice at 4 months of age, #P<0.05 vs. mice at 2 months of age. B: Mitochondrial transcription cascade from exercised mice. Data are presented as mean ± SEM (n = 8) and displayed as fold changes vs. YS mice. The statistical significance of differences was calculated by students' t test. *P<0.05, **P<0.01 vs. OS mice, #P<0.05 vs. YS mice.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0021140.g004