Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart
Figure 5
Surface ECG recordings on wt and dystrophic neonatal and adult mice.
(Top) Typical original ECG signals (lead 1) from neonatal and adult wt mice, and the corresponding averages over 100 beats (insets). (Bottom right) Overlay of representative QRS-complexes (lead 2) in adult wt and mdx mice. In the graph, the QRS intervals of neonatal and adult ECGs are compared between wt and dystrophic mice. *** significant difference (ANOVA, p<0.001, n-values: 6–15) between the three tested groups. No significant differences exist between mdx-utr and mdx.