Elevated miR-499 Levels Blunt the Cardiac Stress Response
Figure 7
miR-499 elevation predisposes to stress-induced cardiac dysfunction in vivo.
(A) Following thoracic aortic banding (TAB), TG-17 hearts were slightly larger compared to banded WT hearts, and (B) the heart-to-body weight ratio was increased to a greater degree in TG-17 compared to similarly banded WT controls (n = 4–5 per group, *P<0.05). (C) Fractional shortening of WT and TG-17 hearts by echocardiography, *P = 0.00079. (D) WGA staining and quantification revealed increased size of cardiomyocytes following TAB. *P<0.05.