Protection against Divergent Influenza H1N1 Virus by a Centralized Influenza Hemagglutinin
Figure 5
Protection against A/PR/8/34 influenza virus infection.
Mice were immunized intramuscularly with various doses of A/PR/8/34, Ad-HA1-con, and A/TX/05/09 HA expressing virus. Three weeks after immunization the mice were challenged intranasally with 100 LD50 of influenza virus A/PR/8/34. Individual mouse weights for the vaccinated mice and the mean and standard error of the control DPBS immunized mice are shown. Mice exhibiting profound signs of disease and less than 75% of baseline weights were humanely sacrificed.