Chemotherapy-Induced Late Transgenerational Effects in Mice
Figure 5
Sperm analysis for control males and males born to DXR-treated mothers over six generations.
(A) A marked decrease in sperm concentration was observed at the first generation (G1) and remained below CON levels for the subsequent five generations studied. (B) Motility on the other hand appeared to improve over several generations. Control males of the same generations do not show significant changes in either the sperm concentrations or sperm motility compared to the Go. *P<0.05; **P<0.001; ***P<0.0001; opened bars (CON); filled bars (offspring of DXR-treated females); the number of mice analyzed per group is provided in parentheses above each bar.