HMMerThread: Detecting Remote, Functional Conserved Domains in Entire Genomes by Combining Relaxed Sequence-Database Searches with Fold Recognition
Figure 4
Multiple sequence alignments of remotely conserved domains in proteins associated with mitosis and meiosis.
(A) Multiple sequence alignment of the Ssp2 family with the RRM_1 domain. (B) Multipe sequence alignment of the Wapl/Rad61 family with the SAP domain family. Residues that are conserved between the two families are highlighted in yellow, those found in only one of them are highlighted in blue and green, respectively. Essential, functional residues retrieved from the CD database are indicated by hash keys, those retrieved from literature (SAP domain) with stars. Accession numbers of sequences can be found in Supplemental Table S7.