MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors
Figure 2
MYC cooperates with PI3K-pathway signaling in bigenic PTENpc−/−/Hi-MYC mice resulting in invasive adenocarcinoma after 3 months.
Mouse prostates (3–4 months), showing high-grade mPIN within glands of the PTENpc−/− and Hi-MYC prostates, and adenocarcinoma in the PTENpc−/−/Hi-MYC prostate. Upper panels: hematoxylin-and-eosin (H&E). Lower panels: Immunohistochemistry (IHC). Note cellular expression of both pAKT and MYC in invasive areas of the PTENpc−/−/Hi-MYC prostate (dashed line), and basement membrane disruption illustrated by loss of collagen IV staining. Scale-bars: 200 µm (black), 400 µM (red).