Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice
Figure 6
Effect of TN3-19.12 on bacillary load, cytokine production and gross pathology.
IgG1 (arrow), TN3-19.12 (arrow) and/or INH treatment (dotted line) were initiated at 14 days post-infection. (A) Bacillary load in mouse lungs. Open diamond, IgG1; Closed diamond, TN3-19.12; Open circle, INH; Closed circle, TN3-19.12+INH, Results are the mean ± SD of 3–4 mice per time point per treatment group. (B) qPCR on mouse lungs collected 28 days post-infection. Results are the mean ± SD of 3–4 mice per time point per treatment group; IgG1- open bars, TN3-19.12- filled bars. * Represents a value of P<0.05 for TN3-19.12 relative to the IgG1 treated mice (control). (C) Gross appearance of the lungs from mice treated with IgG1 (control), TN3-19.12 or CC-3052, with or without INH co-treatment, at 35 days post-infection.