Interferon Gamma-Dependent Intestinal Pathology Contributes to the Lethality in Bacterial Superantigen-Induced Toxic Shock Syndrome
Figure 8
Effect of IFN-γ deficiency on SEB-induced pulmonary immunopathology.
Age-matched HLA-DR3.IFN-γ+/+ (A and C) and HLA-DR3.IFN-γ−/− (B and D) transgenic mice were left untreated (A and B) or challenged with SEB (50 µg, C and D). Mice were killed 48 hrs later, lungs were collected in buffered formalin and processed for H&E. The bar corresponds to 100 µM.