Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice
Figure 4
Effects of immobilization stress on the expression of genes in PVN.
Relative expression levels and changes (stressed/non-stressed) of stress-related genes (Crh, Avp, Oxt, c-fos and Nr3c1) and Per genes (Per1 and Per 2) in PVN of three genotypes (M-WT, Per1 mutant and Per2 mutant) are shown in A–G, respectively. The asterisks (*, p<0.05; **, p<0.01; ***, p<0.001) indicate in each genotype, the significant differences in the gene mRNA expression levels of stressed mice compared to the non-stressed mice, which is designated as 1. # indicate under non-stressed status, the significant differences of relative expression level of genes between Per genes mutant mice and M-WT (#, p<0.05; ##, p<0.01, one way ANOVA).