Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1
Figure 7
Isoflurane anesthesia before euthanasia instead of ether caused a capsaicin-induced enhancement of LA-LTP in horizontal slices derived from adult mice.
(A) HFS-induced LTP is increased in magnitude by 1 µM capsaicin in comparison with control. This increase can be blocked by the specific TRPV1 antagonist AMG9810. (B) Capsaicin-induced LTP enhancement is absent in TRPV1−/− mice. Representative traces were recorded 5 min prior to tetanus (dashed lines) and 60 min after tetanus (solid lines). (C) Bar histogram of data points averaged 57 to 60 min after HFS and normalized with respect to baseline (mean ± SEM). Significant differences are indicated. *p≤0.05.