Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1
Figure 5
NO is involved in the mediation of the suppressive effect of capsaicin on LA-LTP.
(A) The application of the unspecific NOS antagonist L-NAME caused a reduction of LA-LTP and blocked the capsaicin-induced suppression of LA-LTP. (B) In nNOS deficient mice the suppressive effect of capsaicin on LA-LTP is again absent. (C) In wild-type mice the decrease in LA-LTP induced by capsaicin was reproduced. Representative traces were recorded 5 min prior to tetanus (dashed lines) and 60 min after tetanus (solid lines) in the LA. (D) Bar histogram of data points averaged 57 to 60 min after HFS and normalized with respect to baseline (mean ± SEM). Significant differences are indicated. *p<0.05. Recordings were done in horizontal slices derived from adult mice.