Common Variants of TLR1 Associate with Organ Dysfunction and Sustained Pro-Inflammatory Responses during Sepsis
Figure 1
IL-6, IL-1β, IL-10, and CRP serum levels according to the TLR1 248Ser-602Ile haplotype status.
Values represent mean ± SEM biomarker levels at inclusion, at 48 hours, and at 7th day for patients showing homozygosity for the TLR1 248Ser-602Ile haplotype (n = 8) and for the rest of patients (n = 52). Note that values represented correspond to those from the 60 severe septic patients with serum measures available at the three time points. Significance of biomarker differences by the haplotype status was obtained using general linear models (GLM) for repeated measures in a longitudinal analysis assuming a recessive model (CRP, p = 0.024; IL-10, p = 0.015; for IL-1β and IL-6, p≥0.45).